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Category: public health

Perspectives from a state genetics coordinator: Public health’s role in addressing familial hypercholesterolemia (FH) in the United States

a body with exposed heart and an artery with cholesterol and a pedigree in the background

For several years I have pondered what should or could be the state public health agency role in addressing FH. Most of my public health genetics colleagues were actively working on other CDC-labeled tier 1 conditions, such as Lynch syndrome (LS) and Hereditary Breast and Ovarian Cancer syndrome (HBOC). While few, if any, of my Read More >

Posted on by Debra Lochner Doyle, Guest Blogger, State Genetics Coordinator, Washington State Department of Health, Kent, WashingtonLeave a commentTags ,

Trends in CDC Publications in Public Health Genomics, 2012-2016

Most articles by CDC authors in 2012-2016—especially those reporting original data—were focused on non-human (mostly pathogen) genomics

Public health genomics advances the translation of genome-based discoveries into disease prevention and population health. Scientists at the Centers for Disease Control and Prevention (CDC) are using information about human, vector, and pathogen genomes to tackle diverse public health problems, from newborn metabolic disorders to infectious disease outbreaks. For an overview of CDC publications in Read More >

Posted on by Junyu Chen, Department of Epidemiology, Emory University Rollins School of Public Health, Marta Gwinn, CFOL, Inc, and Muin J. Khoury, Office of Public Health Genomics, Centers for disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Precision Public Health: More Precision Ahead for Individual and Population Interventions

people holding a sign reading Medicine & Public Health with DNA

In August 2016, we published a point-counterpoint viewpoint asking a crucial question that has been on the minds of researchers, health care providers and the public health community: “will precision medicine improve population health?” We understood that we were tackling “the elephant in the room” and hoped for reactions to this viewpoint. We were pleased Read More >

Posted on by Muin J. Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia, and Sandro Galea, Dean, School of Public Health, Boston University, Boston, Massachusetts2 CommentsTags ,

Direct-to-Consumer Genetic Testing and Public Health Education

a woman looking at her spit in a test tube, sequencing wrapped around a hand, a person looking at double helix on a monitor, a person discussion her genetic test results with a counslor and a crowd of people

We have previously blogged about the value (or lack thereof) of direct-to-consumer (DTC) genetic tests in improving health. In a 2011 blog entitled “think before you spit” we cautioned that there was very little evidence that the use of such tests improves health and prevents disease for healthy people in the population. The blog was Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , , ,

Genomic discoveries to clinical applications: Are we reaching an inflection point toward precision medicine?

a collage of four image: whole genome sequencing, a hand holding a pen pointing to DNA, a two people in a lab, doctor showing documents to a patient, DNA in the midddle and a family superimposed over all five images

Each year at the annual American Society of Human Genetics (ASHG) meeting I follow certain rituals. During the first “poster session”, I quickly peruse all of the vendor booths on the floor to assess something of the overall flavor of the commercial space’s focus. During the next two poster sessions I cruise all of the Read More >

Posted on by W. Gregory Feero, MD, PhD, Maine Dartmouth Family Medicine ResidencyLeave a commentTags , ,

The Ultimate Selfie

girl seeing a reflection in the water with DNA swimming in it

Now within reach, our personal genomic sequence offers an incredible reflection of who we are, and great promise to improve human health, but there are serious concerns about embracing it too quickly. Empowered Consumers in the Era of Me If social media is any indication, we, like Narcissus of ancient myth, are surely self-obsessed creatures. Read More >

Posted on by Scott Bowen and Muin J Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention3 CommentsTags , , , ,

Precision Public Health and Precision Medicine: Two Peas in a Pod

two peas is a pod: first pea has a crowd of figures with one under a magnifying glass- second pod has that individual being examined by a doctor- the pod has DNA on it

  The 2015 US Precision Medicine Initiative promises a new era of biomedical research and its application in health care. The initiative is enabled by rapid advances in biomedical sciences, including genomics and bioinformatics, as well as the progress in communication, information technologies and data science. Targeted cancer therapies are a near term goal for Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags ,

The Success of Precision Medicine Requires a Public Health Perspective

a magifying glass focusing on a figure in red with surrounding figures in blue

The announcement of a new major US Precision Medicine initiative comes more than a decade after the completion of the Human Genome Project, the ambitious project that culminated in sequencing all 3 billion base pairs of our genome. Continuous improvement in the quality of sequencing, dramatic reduction in price, and ongoing advances in multiple sectors Read More >

Posted on by Muin J Khoury, Director, Office of Public Health Genomics, Centers for Disease Control and Prevention1 CommentTags , ,

Family health history is a non-modifiable risk factor—or is it?

a family biking

“I met three different women who had been tested [genetic testing for mutations in the BReast CAncer susceptibility (BRCA) genes] early on, in 1996, when the BRCA test first came out. They told me their family history story of mothers, aunts, uncles, and a dad who suffered from breast or ovarian or related cancers, and Read More >

Posted on by Ridgely Fisk Green,Office of Public Health Genomics, Centers For Disease Control and PreventionLeave a commentTags , ,

Epigenetics and Public Health: Why We Should Pay Attention

Epigenetics and the Agouti Mouse

In September 2014, one of us (MJK) spoke on the topic of epigenetics at the Annual Meeting of the Association for State and Territorial Health Officials (ASTHO). ASTHO is a national organization representing public health agencies in the United States. ASTHO members formulate and influence public health policy and practice. In the midst of a Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics and Krista Crider, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and PreventionLeave a commentTags , , , ,