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Category: Polygenic Risk Scores

The use of polygenic risk scores in clinical practice can exacerbate health disparities in ethnic and minority populations

This blog is a summary of our recent commentary on polygenic risk scores (PRS). PRS provide a rapidly emerging example of precision medicine and are based on multiple gene variants that each have weak associations with disease risks, but collectively may enhance disease predictive value in the population. The added value of PRS is unclear Read More >

Posted on by Megan C Roberts, UNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy; Muin J Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention; George A Mensah, Center for Translation Research and Implementation Science, National Institutes of Health, National Heart, Lung, and Blood Institute1 CommentTags , , ,

Is it Time to Integrate Polygenic Risk Scores into Clinical Practice? Let’s Do the Science First and Follow the Evidence Wherever it Takes Us!

a polygenetic risk score bell curve and DNA, lab techinicians working in a lab and a doctor talking to his patient

In case you have not been paying much attention to genomic medicine research or social media coverage, you might have missed a clear uptick in the past couple of years  on the value of polygenic risk scores in clinical practice and population screening. (see examples here, here, here, and here) Polygenic risk scores (PRS) summarize Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; and George A. Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, Blood Institute, Bethesda, Maryland1 CommentTags ,

Research on the Behavioral Impact of Polygenic Risk Scores: The Train Has Already Left the Station!

a Polygenic Risk Scores with a train leaving the station

There has been a lot of discussion recently about the new generation of polygenic risk scores (information about a person’s disease risk based on many dozens, hundreds, thousands, or even millions of common DNA variants in their genome), and whether these new-and-improved genetic risk scores are going to turn out to be useful for disease Read More >

Posted on by Saskia Sanderson, Guest Blogger, University College London Institute of Health Informatics, London, United Kingdom and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags
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