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Category: genomics

Implementation science and genomic medicine in action: A case study

lab workers and DNA

There is an urgent need for researchers and implementers of genomic medicine to incorporate implementation science into their translational research efforts. Implementation science is the study of methods to promote the adoption and integration of evidence-based practices, interventions, and policies into routine healthcare and public health settings to improve our impact on population health. But Read More >

Posted on by Mindy Clyne, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Precision Medicine Update: Important Progress on the Long Road from Discovery to Population Health Impact

a long road with DNA and the text Discovery and Population Health Impact

Impressive Pace and Potential The All of Us Research Program is an ambitious United States initiative launched in 2015 to collect health-related information on one million or more volunteers from diverse communities. A recent paper in the New England Journal of Medicine described progress and lays out the vision for the initiative moving forward. As Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta Georgia and George A. Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, and Blood InstituteLeave a commentTags

Can a Healthy Lifestyle Reduce Your Risk of Dementia Regardless of Your Genes?

a hand writing Dementia with bar bells and an apple wrapped in a measuring tape and DNA

A large retrospective, cohort study found that a healthy lifestyle is associated with a lower risk for dementia among people considered at high genetic risk. An active lifestyle, which includes a nutritious diet, limited alcohol, and not smoking, has long been associated with reduced risk of cancer and heart disease. In the last ten years, Read More >

Posted on by Scott Bowen, Office of Public Health Genomics; Christopher Taylor, Division of Population Health, National Center for Chronic Disease Prevention and Health Promotion; and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Why should early career public health researchers pay attention to precision medicine?

one main figure connect to three others

In a recent commentary published in the American Journal of Public Health, I had the privilege of working with a group of early career investigators to begin a conversation about the impact that the debate between the utility of precision medicine and public health approaches is having as we begin our research careers. To begin, let’s Read More >

Posted on by Caitlin G. Allen, MPH, Doctoral Student, Behavioral Sciences and Health Education Department, Emory University Rollins School of Public Health, Atlanta, GeorgiaLeave a commentTags

The use of polygenic risk scores in clinical practice can exacerbate health disparities in ethnic and minority populations

This blog is a summary of our recent commentary on polygenic risk scores (PRS). PRS provide a rapidly emerging example of precision medicine and are based on multiple gene variants that each have weak associations with disease risks, but collectively may enhance disease predictive value in the population. The added value of PRS is unclear Read More >

Posted on by Megan C Roberts, UNC Eshelman School of Pharmacy, Division of Pharmaceutical Outcomes and Policy; Muin J Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention; George A Mensah, Center for Translation Research and Implementation Science, National Institutes of Health, National Heart, Lung, and Blood Institute1 CommentTags , , ,

Can Big Data Science Deliver Precision Public Health?

a big data word globe held by a person and a crowd of people with a small group being focused on

This blog is a quick summary of our recent paper in Public Health Genomics.   Increasingly, a large volume of health and non-health related data from multiple sources is becoming available that has the potential to drive health related discoveries and implementation. The term “big data” is often used as a buzzword to refer to large Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; Michael Engelgau, George A. Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, and Blood Institute, Bethesda, Maryland; David A. Chambers, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MarylandLeave a commentTags

Introducing the CDC Tier-Classified Guidelines Database

a database image with Tier 1 in green, Tier 2 in yellow and Tier 3 in red

Over the last several years, OPHG has hosted a “Tier Table” database of genomic applications (i.e., clinical scenarios involving genomic testing) sorted into one of three tiers using a method described in Clinical Pharmacology and Therapeutics, 2014. The purpose of creating the database was to help organize evidence (such as recommendation statements contained in guidelines, Read More >

Posted on by W. David Dotson, Wei Yu, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags ,

Frequently Asked Questions about the CDC Tier-Classified Guidelines Database

Over the last several years, OPHG has hosted a “Tier Table” database of genomic applications (i.e., clinical scenarios involving genomic testing) sorted into one of three tiers using a method described in Clinical Pharmacology and Therapeutics, 2014. The Tier Table is being replaced with our new Tier-Classified Guidelines Database, which we hope will promote more Read More >

Posted on by W. David Dotson, Wei Yu, and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and PreventionLeave a commentTags , ,

Is it Time to Integrate Polygenic Risk Scores into Clinical Practice? Let’s Do the Science First and Follow the Evidence Wherever it Takes Us!

a polygenetic risk score bell curve and DNA, lab techinicians working in a lab and a doctor talking to his patient

In case you have not been paying much attention to genomic medicine research or social media coverage, you might have missed a clear uptick in the past couple of years  on the value of polygenic risk scores in clinical practice and population screening. (see examples here, here, here, and here) Polygenic risk scores (PRS) summarize Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; and George A. Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, Blood Institute, Bethesda, Maryland1 CommentTags ,

Can Predictive Analytics Drive Implementation Research to Improve Population Health?

a crowd of people incased in an upward arrow with a magifying glass on them with DNA

To date, research investments have yielded many highly effective health interventions for disease prevention and treatment. Examples include smoking cessation, lipid and blood pressure control as well as diet and physical activity interventions. Yet, many interventions are not being optimally delivered to have public health impact. Implementation research can provide a means to determine optimal Read More >

Posted on by Michael Engelgau, George A. Mensah, Center for Translation Research and Implementation Science, National Heart, Lung, Blood Institute, National Institutes for Health, Bethesda, Maryland and Muin J. Khoury, Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,
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