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Genomics and Precision Health Posts

Reducing the Global Public Health Burden of Familial Hypercholesterolemia: More Work Ahead

a map of the world, an artery clogged with cholesterol and a pedigree with hearts

In our previous blog, we discussed familial hypercholesterolemia as a prototype for “precision public health” and how the combination of public health and genetic approaches can contribute to raising awareness, diagnosis, and treatment of more than 1 million individuals in the United States with this relatively common genetic condition. Familial hypercholesterolemia (FH) is an underdiagnosed Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health; and Betsy L. Thompson, Division for Heart Disease and Stroke Prevention. Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

“Precision” Health Tools and… Increased Health Disparities?

a doctor talking to his patient under a magnifying glass over a crowd of people

Working from the perspective of public health, we have frequently expressed concerns about the potential of precision health technology to exacerbate health disparities. Many of these discussions have focused on genomic-based approaches such as using polygenic risk scores (PRS) for a wide array of disease and health outcomes. Because of minority underrepresentation in basic research, Read More >

Posted on by Scott Bowen, Muin J Khoury, Office of Public Health Genomics and Precision Public Health; Ramal Moonesinghe, Office of Minority Health and Health Equity – Centers for Disease Control and Prevention; and George A Mensah, Center for Translation Research and Implementation Science, National Institutes of Health, National Heart, Lung, and Blood InstituteLeave a commentTags ,

Progress in Pathogen Genomics as a Prototype for Precision Public Health

four arrows labeled Bacterial Foodborne Illness, Parasitic Diseases, Tuberculosis and Influenza pointing to Pathogen Genomics: A Prototype for Precision Public Health with DNA around

Rapid advances in pathogen genomics have ushered in a new era of “precision public health.” Next-generation sequencing is already enabling more effective investigations of outbreaks of foodborne illnesses, better-targeted tuberculosis control, and more timely and granular influenza surveillance to inform the selection of vaccine strains. In a recent paper in the New England Journal of Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Communication and Information Sharing about Genomics and Precision Health: Opportunities for Improvement

several hands holding puzzle pieces labeled PHGKb, Genomic Blog, Twitter Posts, Weekly Update, Tiered Evidence, an image of a bullhorn, three people conversing and a magnifying glass. These puzzle pieces are being pushed together to a center piece in red with DNA.

In this blog, we describe our current approach to information sharing based on a recent review of our communication and engagement strategies. In order to improve our approaches to communication, we are asking you, our readers, for feedback—please share your thoughts in the comments section below or send us an email at mailto:genetics@cdc.gov. For the Read More >

Posted on by Caitlin G. Allen, Ridgely Fisk Green and Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags , , ,

Genomic Medicine Year in Review 2019: What’s Hot for Public Health Impact?

2019 to 2020 with fireworks

Advances in genomic medicine continue at a fast and steady pace. In a recent paper, The Genomic Medicine Working Group of the National Advisory Council for Human Genome Research of the National Human Genome Research Institute identified the most significant advances in genomic medicine among 48 recognized “accomplishments” published during the 12 months ending August 31, Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags ,

Are we Ready for DNA-based Population Screening? The Need for Large Collaborative Pilot Studies

a maginfying glass with DNA looking at a crowd

This blog is a summary of a recent viewpoint published in the Journal of American Medical Association. There is increasing evidence that accepted approaches using medical history-based screening fail to identify the majority of individuals with genetic conditions associated with cancer and heart disease, including CDC tier 1 applications, such as hereditary breast and ovarian Read More >

Posted on by Michael Murray, Yale University; James Evans, University of North Carolina; Betsy Thompson and Muin J. Khoury, Centers for Disease Control and PreventionLeave a comment

Happy Thanksgiving 2019: Collect and Share Your Family Health History: It Could Save Your Life!

a multi generational family sharing a Thanksgiving meal

Happy Thanksgiving Day! It is time for our yearly message on the importance of family health history to your own health. Year after year we promote the value on family health history around Thanksgiving day and all year round. By knowing and acting on your family history, you can reduce your disease risk and actually Read More >

Posted on by Muin J Khoury, Director, Office of Genomics and Precision Public Health, Centers for Disease Control and PreventionLeave a comment

Familial Hypercholesterolemia as a Prototype for Precision Public Health

Dr Khoury and Dr. Thompson

In October 2019, the 7th annual FH Foundation global summit on familial hypercholesterolemia (FH) took place in Atlanta, Georgia. The theme of the conference was, “Familial Hypercholesterolemia as a Prototype for Precision Public Health.” The meeting brought more than 300 participants from multiple countries to discuss the latest advances in the diagnosis, screening, treatment and Read More >

Posted on by Muin J. Khoury, Office of Public Health Genomics and Betsy L. Thompson, Division for Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a commentTags

Public Health Perspectives on Ensuring Life Long Benefits of Newborn Screening

a newborns foot

This blog post is a summary of a Perspective recently published in Pediatrics that was authored by Alex Kemper of Nationwide Children’s Hospital, Jeffrey Brosco of the Miller School of Medicine, University of Miami, and Coleen Boyle and Scott Grosse of CDC’s National Center on Birth Defects and Developmental Disabilities. Newborn screening is a highly Read More >

Posted on by Muin J. Khoury, Office of Genomics and Precision Public Health, Centers for Disease Control and Prevention, Atlanta, GeorgiaLeave a comment

Many Adults with Familial Hypercholesterolemia Are Not Meeting Goal LDL-Cholesterol Level

a group of adults and a drop of blood with LDL-C and an up arrow

People with the genetic disorder familial hypercholesterolemia (FH) have increased blood levels of low-density lipoprotein (LDL) cholesterol, which increases their risk for developing coronary artery disease or having a heart attack. A recent study using data from the FH Foundation’s CASCADE FH Registry suggests that many individuals with FH are not meeting blood LDL-cholesterol level Read More >

Posted on by Ridgely Fisk Green, Carter Consulting, Inc. and Office of Genomics and Precision Public Health, Office of Science, Centers for Disease Control and Prevention; Caitlin G. Allen, Behavioral Sciences and Health Education Department, Rollins School of Public Health, Emory University; Quanhe Yang, Epidemiology and Surveillance, Division for Heart Disease and Stroke Prevention, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and PreventionLeave a commentTags ,
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